Functional and evolutionary characterization of a secondary metabolite gene cluster in budding yeasts
نویسندگان
چکیده
منابع مشابه
Molecular Characterization of a Fungus Producing Membrane Active Metabolite and Analysis of the Produced Secondary Metabolite
Background: The majority of studies on soil Aspergillus concern the isolation and characterization of the antimicrobial compounds produced by this organism. Our previous studies indicated an isolated Aspergillus strain soil to be of interest, and this subject is further investigated here. Method: Soil samples of various locations in Iran were collected. Extract from Aspergillus sp. culture was...
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The secondary metabolite gene clusters of euascomycete fungi are among the largest known clusters of functionally related genes in eukaryotes. Most of these clusters are species specific or genus specific, and little is known about how they are formed during evolution. We used a comparative genomics approach to study the evolutionary origins of a secondary metabolite cluster that synthesizes a ...
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The fungus F. fujikuroi is well known for its production of gibberellins causing the 'bakanae' disease of rice. Besides these plant hormones, it is able to produce other secondary metabolites (SMs), such as pigments and mycotoxins. Genome sequencing revealed altogether 45 potential SM gene clusters, most of which are cryptic and silent. In this study we characterize a new non-ribosomal peptide ...
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در طی چند دهه ی اخیر، مفهوم «تراژدی» و «قهرمان تراژدی» توجهی روزافرون را تقریباً در تمام حوزه های نقد ادبی به خود معطوف کرده است. برخی نظیر ارسطو، نیچه، و آرتور میلر به بازخوانی آن پرداخته و برخی دیگر نظیر سارتر، استریندبرگ، یوجین اُنیل، برتولت برشت، و آنتونین آرتود به افزودن ابعاد نوینی به این مبحث همت گماشته اند. آنچه قهرمان تراژدی مدرن را از مفهوم کلاسیک آن متمایز می کند نه لغزش تراژیک متداول ...
Regulation of a novel gene cluster involved in secondary metabolite production in Streptomyces coelicolor.
Antibiotic biosynthesis in the streptomycetes is a complex and highly regulated process. Here, we provide evidence for the contribution of a novel genetic locus to antibiotic production in Streptomyces coelicolor. The overexpression of a gene cluster comprising four protein-encoding genes (abeABCD) and an antisense RNA-encoding gene (α-abeA) stimulated the production of the blue-pigmented metab...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1806268115